"我今晚其实正在创造历史，作为第一个担任SNL主持人的亚斯伯格人。或者至少是第一个承认这一点的人。所以我今晚不会和演员们进行很多眼神交流。但不用担心，我在运行人类模拟模式方面相当擅长。"

Simplified Meaning:

The person is saying that they have Asperger's syndrome, a condition that affects how they interact socially, making things like eye contact difficult. Despite having Asperger's, they have achieved something significant by hosting a popular TV show, Saturday Night Live (SNL). They joke that they might avoid looking directly at people during the show, a common trait among those with Asperger's. However, they also reassure the audience that they can still perform well by imitating typical social behaviors, which they call "human and emulation mode." To relate this to everyday life, consider someone who has difficulty working in noisy environments but still manages to thrive at their job by using noise-canceling headphones. They adapt to their challenge and find a way to succeed. This explanation shows others that even if you have a condition that affects your social interactions or other aspects of life, you can still achieve great things by finding ways to manage and overcome those challenges.