“I'm actually making history tonight as the first person with Asperger's to host SNL. Or at least the first to admit it. So I won't make a lot of eye contact with the cast tonight. But don't worry, I'm pretty good at running human and emulation mode.”

Simplified Meaning:

The person is saying that they have Asperger's syndrome, a condition that affects how they interact socially, making things like eye contact difficult. Despite having Asperger's, they have achieved something significant by hosting a popular TV show, Saturday Night Live (SNL). They joke that they might avoid looking directly at people during the show, a common trait among those with Asperger's. However, they also reassure the audience that they can still perform well by imitating typical social behaviors, which they call "human and emulation mode." To relate this to everyday life, consider someone who has difficulty working in noisy environments but still manages to thrive at their job by using noise-canceling headphones. They adapt to their challenge and find a way to succeed. This explanation shows others that even if you have a condition that affects your social interactions or other aspects of life, you can still achieve great things by finding ways to manage and overcome those challenges.