“I don't drink these days. I am allergic to alcohol and narcotics. I break out in handcuffs”
— Robert Downey Jr.
Simplified Meaning:
When someone says they are allergic to alcohol and drugs, and they "break out in handcuffs," they mean that whenever they drink or use drugs, they tend to get in trouble with the law and end up being arrested. It’s a humorous way of saying that drinking and using drugs always lead to bad situations for them. For example, imagine John. Every time John goes to a party and drinks too much, he starts fights, drives dangerously, or does other things that get the police involved. He ends up in jail because of his actions while under the influence. So, John decides to stop drinking to avoid these problems. People can use this idea to think about their own habits. If something you do always causes problems, maybe it’s a good idea to stop doing it. In John's case, avoiding alcohol helps him stay out of trouble and live a better life. This idea can apply to other bad habits too. If certain actions always lead to trouble, stopping those actions can help you avoid negative outcomes.